Route 139 is a highway in northern and central Missouri. Its northern terminus is at the Iowa state line where it continues as Wayne County Route S40; its southern terminus is at U.S. Route 24 east of Carrollton.

County	Location	mi	km	Destinations	Notes
Carroll	Leta	0.000	0.000	US 24 – De Witt, Carrollton
Chariton	No major junctions
Linn	Jefferson Township	34.281	55.170	Route 130 north – Forker
		38.372	61.754	US 36 east / Route 110 (CKC) east / Route 5 – Laclede, Brookfield	Southern end of US 36 / Route 110 overlap
		40.264	64.799	Route 130 south – Pershing State Park
	Parson Creek Township	45.163	72.683	US 36 west / Route 110 (CKC) west / Route W – Fountain Grove, Chillicothe	Northern end of US 36 / Route 110 overlap
Sullivan	Humphreys	69.574	111.968	Route 6 east – Milan	Southern end of Route 6 overlap
Grundy	Liberty Township	72.362	116.455	Route 6 west – Galt	Northern end of Route 6 overlap
Sullivan	No major junctions
Putnam	Medicine Township	97.345	156.662	US 136 west – Princeton	Southern end of US 136 overlap
	Medicine–York township line	100.726	162.103	US 136 east – Unionville	Northern end of US 136 overlap
	York Township	108.565	174.718	CR S40 north	Continuation into Iowa
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus