Mitchell is an unincorporated community in Rice County, Kansas, United States. Located about 6 miles (9.7 km) east-northeast of the city of Lyons, it lies along local roads a fraction of a mile (less than 1 km) north of U.S. Route 56.

For millennia, the land now known as Kansas was inhabited by Native Americans. In 1803, most of modern Kansas was secured by the United States as part of the Louisiana Purchase. In 1854, the Kansas Territory was organized, then in 1861 Kansas became the 34th U.S. state. In 1867, Rice County was founded.

In 1878, Atchison, Topeka and Santa Fe Railway and parties from Marion County and McPherson County chartered the Marion and McPherson Railway Company. In 1879, a branch line was built from Florence to McPherson, in 1880 it was extended to Lyons, in 1881 it was extended to Ellinwood. The line was leased and operated by the Atchison, Topeka and Santa Fe Railway. The line from Florence to Marion, was abandoned in 1968. In 1992, the line from Marion to McPherson was sold to Central Kansas Railway. In 1993, after heavy flood damage, the line from Marion to McPherson was abandoned. The original branch line connected Florence, Marion, Canada, Hillsboro, Lehigh, Canton, Galva, McPherson, Conway, Windom, Little River, Mitchell, Lyons, Chase, Ellinwood.

A post office was opened in Mitchell in 1882, and remained in operation until it was discontinued in 1953.

The community is served by Lyons USD 405 public school district.

• Leo B. Bozell - Advertising executive, born in Mitchell.

• Rice County maps: Current, Historic - KDOT