Mitchells Presbyterian Church is a historic Presbyterian church located on VA 652 in Mitchells, Culpeper County, Virginia. It was built in 1879, and is a one-story, frame building in the Carpenter Gothic style. It measures 50 feet by 30 feet and sits on a brick foundation. The interior features a trompe-l'œil fresco added between 1892 and 1899 by well-known local artist Joseph Oddenino. He also painted the interior murals at Elmwood.

It was listed on the National Register of Historic Places in 1980.