Monroe Tavern, also known as McMasters Tavern, is a historic home that also served as an inn and tavern located at South Union Township, Fayette County, Pennsylvania. It was built about 1825, and is a 2+1⁄2-story, 5-bay, sandstone building with a center hall floor plan in an Early Republic style. It has a 2+1⁄2-story, kitchen ell. It served as a stop for 19th-century travelers on the National Road.

It was added to the National Register of Historic Places in 1995.