Moore-Manning House is a historic home located at Pittsboro, Chatham County, North Carolina. It was built in the 1830s, and is a two-story, three-bay, Federal style frame dwelling with a hipped roof. The house was renovated in 1858 and a two-story wing added.

It was listed on the National Register of Historic Places in 1982. It is located in the Pittsboro Historic District.