Mosely Creek is a large creek in the Pacific Ranges of the Coast Mountains in British Columbia, Canada, flowing southwest to join the Homathko River in its canyon downstream from Tatlayoko Lake, and a short distance above Murderers Bar at 51°16′00″N 124°54′00″W / 51.26667°N 124.90000°W / 51.26667; -124.90000 (Murderers Bar), which is the site of the opening events of the Chilcotin War of 1864.

Tiedemann Creek, which begins at the Tiedemann Glacier on Mount Waddington, is a tributary of Mosley Creek, flowing east from its source to the confluence at 51°18′38″N 124°50′39″W / 51.31056°N 124.84417°W / 51.31056; -124.84417 (Tiedemann Creek), just above the confluence with the Homathko.

The creek is named for Edwin Mosley or Mosely who was one of three settler survivors of the Chilcotin War of 1864.

Also flowing into Mosley Creek is Tellot Creek at 51°21′07″N 124°53′40″W / 51.35194°N 124.89444°W / 51.35194; -124.89444 (Tellot Creek), flowing southeast, which was named for one of the war chiefs of the Tsilhqot'in who took part in the massacre of Alfred Waddington's work party that touched off the Chilcotin War.

• List of rivers of British Columbia