The Mud River is a tributary of the Guyandotte River in southwestern West Virginia in the United States. Via the Guyandotte and Ohio Rivers, it is part of the Mississippi River watershed. The river is popular with muskellunge anglers.

The Mud River was so named on account of the muddy character of its water.

The Mud River rises in Boone County, west of Madison, and flows generally northwestward for 72 mi (116 km) through Lincoln and Cabell counties, past the towns of Hamlin and Milton. It meets the Guyandotte at the town of Barboursville. Near the stream's mouth, the Mud River meanders through the large, ancient valley of the Teays River.

• List of rivers of West Virginia

• Allrefer.com: Mud River location
• WVgameandfish.com: Mud River popularity with anglers

38°24′58″N 82°17′44″W / 38.41611°N 82.29556°W / 38.41611; -82.29556