Murrells Inlet Historic District is a national historic district located at Murrells Inlet, Georgetown County, South Carolina. The district encompasses 37 contributing buildings and contains a significant concentration of buildings that visually reflect the transition of the area from adjoining estates of two 19th-century rice planters into a 20th-century resort community. The district contains two antebellum houses, which are local interpretations of the Greek Revival style and a collection of early-20th-century vernacular resort buildings. Residential in character, the historic district contains approximately 19 houses. Although they exhibit some diversity, the prevalent use of wood as a building material, the large screened porches, and the setting of moss-draped trees, marshland, and piers provide a visual unity.

It was listed on the National Register of Historic Places in 1980.