The Muskogee Turnpike, also designated State Highway 351 (SH-351), is a controlled-access toll road in eastern Oklahoma.

Opened in 1969, the 53-mile (85.2 km) route begins at the Broken Arrow Expressway (SH-51) southeast of Tulsa, near an intersection with the Creek Turnpike. The Turnpike ends at Interstate 40 west of Webbers Falls. The Muskogee Turnpike's north section is connected to its south section by Oklahoma 165.

This section needs expansion. You can help by adding to it. (March 2014)

The Muskogee Turnpike originally bore no numbered designation. On March 10, 2014, the Oklahoma Transportation Commission unanimously approved a motion to apply the SH-351 designation to the turnpike.

As of August 2023, a two-axle vehicle pays $7.00 PlatePay ($3.30 with Pikepass) to drive the full length of the Turnpike. There are two toll collection plazas located along the length of the Muskogee Turnpike. The Muskogee Main Line Plaza is located approximately 5 miles (8.0 km) south of the city of Muskogee and has an inline Pikepass lane, an exact change lane, and an attended collection lane. Speed limits through this plaza are 30 miles per hour (48 km/h) for all vehicles. The Coweta Main Line Plaza is located approximately 15 miles (24 km) north of the city of Muskogee at the Coweta exit, and has four collection lanes: one exact change lane, two attended lanes, and a Pikepass lane that is independent from the plaza. The speed limit at this plaza is 30 miles per hour (48 km/h) for all vehicles, except Pikepass vehicles, which bypass the collection plaza.

Located approximately 10 miles (16 km) north of the city of Muskogee is a newly renovated concession plaza which reopened in April 2011. This concession plaza has an EZ Go gasoline station selling Phillips 66 gasoline, as well as a McDonald's restaurant. The concession plaza has free restrooms, is open 24 hours a day, and is located in the median for easy access from both travel directions. Groundwork was laid out for a second concession plaza just north of the Muskogee Main Line collection plaza; however this plaza was never built, and all pavement and ramps have since been removed.

Law enforcement along the Muskogee Turnpike is provided by Oklahoma Highway Patrol Troop XB, a special troop assigned to the turnpike.

County	Location	mi	km	Exit	Destinations	Notes
Wagoner	Broken Arrow	0.0	0.0		SH-51 west (Broken Arrow Expressway)	Western terminus
					SH-51	Eastbound entrance only
				—	SH-364 / Creek Turnpike east	SH-364 not signed westbound; no toll from EB Muskogee Tpk. to WB Creek Tpk.
	Coweta			13	SH-51 – Wagoner, Coweta
				Coweta Main Line Plaza
	​			19	To SH-51B – Porter	Eastbound exit and westbound entrance
	​			Turnpike Concession
	​			26	US 69 – Muskogee, Wagoner	Westbound toll
Muskogee	Muskogee			33	Hyde Park Road – Port of Muskogee, War Memorial Park	No exit number northbound
				​	SH-165 begins Free section begins
		34	55	—	US 62 – Muskogee, Bacone College, NSU Muskogee, Fort Gibson, Tahlequah
		35	56	—	Gibson Street
		36	58	—	Chandler Road / Hancock Street	Hancock St. signed eastbound only
		37	60	—	SH-165 west (Peak Boulevard) to US 64	Eastbound exit and westbound entrance
				Free section ends
	​			37	To SH-165 west (Hancock Street)	Westbound exit only
	​			Concession plaza
	​	42	68	Muskogee Main Line Plaza
	Webbers Falls	55.56	89.42	55	US 64 – Webbers Falls, Warner	Eastbound exit and westbound entrance
				56A-B	I-40 – Oklahoma City, Fort Smith	Eastern terminus; signed as exits 56A (west) and 56B (east); I-40 exit 286
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus       Closed/former       Incomplete access        Tolled

• Oklahoma Turnpike Authority
• Pikepass

• Muskogee Turnpike Toll/Fares Chart - Oklahoma Turnpike Authority