Centre Hospitalo-Universitair Mustapha Pacha (French: Centre Hospitalo-Universitaire Mustapha d'Alge) was founded in 1854 in the town of Moustapha (now Sidi M'Hamed) and is the largest hospital in Algeria.

This hospital center is one of 14 Centre Hospitalo-Universitair under the Algerian Ministry of Health, Population and Hospital Reform.

The hospital was established by a legacy of a rich settler named Fortin, a native of Ivry, in the city of Algiers. In his will of 19 September 1840, he donated a sum of 1.2 million francs for the erection of a civilian hospital in Mustapha.

At its inception in 1854, it was a military hospital with a barracks on 8 hectares. On 21 May 1855, the civilian doctors courses were open to students, and on 18 January 1859, official courses were inaugurated in the framework of the new School of Medicine of Algiers founded in 1857.

After 1877, 14 pavilions were built to plans by the architect Jules Voinot. The first services were those of Pediatrics in 1883 and obstetrics in 1884. It was decided in 1920 to expand the hospital. The number of pavilions was doubled by 1930. There has been continual expansion since then.

Mustapha Pacha, Mustapha VI ben Brahim Pasha (Arabic  : مصطفى بن ابراهيم باشا ), or Mustafa ben Brahim was dey of Algiers between May 1798 and the August 31, 1805, date of his assassination by a Janissary.. 

The hospital provides the following services:

• Jean Baptiste Paulin Trolard (1869), anatomist
• Jules Aimé Battandier (1876), botanist
• Louis Charles Trabut (1880), doctor and botanist
• Omar Boudjellab (1970), cardiologist
• Tedjini Haddam (1970), thoracic surgeon