Mypolonga is a rural town in South Australia, situated on the western side of the lower Murray River, between Mannum and Murray Bridge. It currently has a local post office/general store, a local primary school and an Australian Rules Football team that participates in the River Murray Football League.

Mypolonga's name derives from an Aboriginal expression meaning "cliff lookout place".

The town is surrounded by limestone cliffs along the Murray River and has much agricultural land. It has been named as a finalist in the 2021 South Australian Ag Town of the Year award.

Key agriculture products include cow's milk, Jonesey's buffalo milk, stone fruit (apricots, peach, nectarine, plums etc.), citrus, wine grapes and olives.

• List of cities and towns in South Australia

• Savvas, Michael X. (21 April 2020). "Good Country: Mypolonga, an unmissable river spot". The Adelaide Review.