N'Douffoukankro is a town in central Ivory Coast. It is a sub-prefecture of Bouaflé Department in Marahoué Region, Sassandra-Marahoué District.

N'Douffoukankro was a commune until March 2012, when it became one of 1126 communes nationwide that were abolished.

In 2014, the population of the sub-prefecture of N'Douffoukankro was 29,097.

The 8 villages of the sub-prefecture of N'Douffoukankro and their population in 2014 are:

1. Akowébo (2 103)
2. Attossè (3 627)
3. Benou (1 784)
4. Blé (3 727)
5. Diacohou-Sud (5 323)
6. Nangrekro (3 453)
7. N'dénoukro (2 889)
8. N'douffoukankro (6 191)