The Quirino Highway, formerly called the El Quirino Express Road or Ipo Road, is a four-to-eight lane, secondary highway that connects Quezon City to the municipality of Norzagaray in Bulacan, Philippines. The road is designated as National Route 127 (N127) of the Philippine highway network within the city bounds of Quezon City, Radial Road 7 (R-7), and a spur of Radial Road 8 (R-8) of Metro Manila's arterial road network.

Prior to the construction of the Balintawak Interchange and North Diversion Road, it forms an old road that linked the city of Manila with Novaliches, previously called as the Manila-del Monte Garay Road, Manila-Novaliches Road, Bonifacio-Manila Road, Balintawak-Novaliches Road, and Highway 52. The portion of the road south of EDSA is presently known as A. Bonifacio Avenue. Circa 1955, the section of the highway from Novaliches to the Caloocan–San Jose del Monte boundary was called Novaliches-San Jose Road.

It was later changed to the Don Tomas Susano Road, after the first officially recognized political leader of the district and municipal president of Caloocan during the American occupation of the Philippines. The name changed once more to Quirino Highway, right after the death of Philippine President Elpidio Quirino, who had resided and died at a nearby retreat house in Quezon City. It was the historical reversed widening of a highway, to narrow down for public use.

Quirino Highway starts from Epifanio de los Santos Avenue, near the Balintawak Cloverleaf in Quezon City. It then runs shortly in parallel to North Luzon Expressway (NLEX) carrying one-way northbound traffic and turns northeast towards the northwestern part of Quezon City. It then meets the Old Novaliches and New Novaliches Flyovers, connecting it to NLEX. The highway turns right at Novaliches Proper, approaching the area of Fairview, where it becomes a one-way westbound highway between Belfast Street to Regalado Highway, adjacent to Robinsons Novaliches and SM City Fairview. Its length from there to Araneta Avenue in Pangarap Village, Caloocan is followed by the under-construction elevated MRT Line 7 line. The road ends its N127 designation as it enters north Caloocan. Crossing the Marilao River, it then enters the province of Bulacan at San Jose del Monte, straddling along the mountainous terrain, and ends at the roundabout with Villarama Road and Ipo Road in Bigte, Norzagaray. Past the roundabout, it is continued by Ipo Road that leads to Ipo Dam.

The highway is also the alternate route for motorists en route to Baliwag and up to Cagayan Valley via Cagayan Valley Road.

Intersections are numbered by kilometer post, with Rizal Park in Manila designated as kilometer zero. 

Province	City/Municipality	km	mi	Destinations	Notes
Quezon City				AH 26 (N1) (EDSA)	Southern terminus; accessible from EDSA northbound.
				East Service Road	Northbound entrance only.
		10	6.2	AH 26 (E1) / N160 (NLEX) – Manila	Access to NLEX southbound and West Service Road and entry from NLEX northbound.
				Santa Quiteria Street / Howmart Road — Reparo
				Mendez Road / Caroline Street — Bahay Toro
				Tandang Sora Avenue / Tullahan Road — Santa Quiteria, Bahay Toro, Culiat
				N128 (Mindanao Avenue) – Kaybiga, Valenzuela, North Triangle	Access to C-5 and E5 (NLEX Mindanao Avenue Link)
				King Alexander Street, Don Julio Gregorio Street (Sauyo Road) — Sauyo, Fairview, Novaliches Proper
				E5 (NLEX Segment 8.2) – Valenzuela, Malabon, Bulacan	Future Quirino Highway Interchange of NLEX Segment 8.2 (NLEX–C-5 / NLEX Citi Link)
				Pagkabuhay Street	Access to Bagbag Cemetery.
				Pablo Dela Cruz Street — Novaliches Proper, San Bartolome	Access to Holy Cross Memorial Park.
				Forest Hill Drive — Santa Monica, Fairview, Lagro
				Sarmiento Street	Traffic light intersection. Vehicles approaching Novaliches Proper are not allowed to turn left.
				N118 (General Luis Street) / Susano Road – Camarin, Caloocan, Valenzuela	Novaliches Proper.
				F. Salvador Street — Fairview, Lagro, Diliman	Jordan Plains Subdivision Phase 1 & 2. A major backroad to Commonwealth Avenue before its extension to Quirino Highway.
				N170 (Commonwealth Avenue) – Diliman, Quezon Memorial Circle, San Mateo	Change from R-8 (spur) to R-7.
				Zabarte Road — Camarin, Bagong Silang
				Belfast Avenue	Eastbound vehicles are shifted here as Quirino Highway becomes one-way westbound. Also accessible westbound. Provides access to Mindanao Avenue.
				Maligaya Street — Camarin, Bagong Silang	Access to Fairview Terraces and Robinsons Novaliches.
				Regalado Highway	Shift from one-way westbound to two-way, four-lane highway.
				Ascension Avenue — Greater Lagro
				St. James Street	Access to Sacred Heart Village in Caloocan.
				Esperanza Street	Access to Our Lady of Fatima University Quezon City.
				La Mesa Road	Controlled access road leading to La Mesa Dam and Reservoir.
Quezon City – Caloocan boundary				Quezon City 1st District Engineering Office–Metro Manila 2nd District Engineering Office highway boundary (Route change from N127 to unnumbered route)
Caloocan				Makabud Street — Amparo
				Malanting Street — Amparo
				Crispulo Street — Camarin, Amparo
				Araneta Avenue	Access to Pangarap Village and Ciudad Real
		28	17	Malaria Road — Tala
Marilao River		28.892– 29.928	17.953– 18.596	Alat–San Jose Bridge
Bulacan	San Jose del Monte			Santa Maria–Tungkong Mangga Road — Santa Maria, Bocaue, Marilao
				Skyline Road
				Francisco Avenue	Access to Francisco Homes Subdivision
				Kaypian Road	Access to Bulacan State University and San Jose del Monte city proper
				Igay Road — Rodriguez
				Del Monte Road
				Dr. Eduardo V. Roquero Sr. Avenue	Access to the Sapang Palay Resettlement Project
	Norzagaray			Villarama Road / Ipo Road — Norzagaray, Angat	Northern terminus; roundabout intersection.
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Closed/former       Incomplete access       Route transition       Unopened

• Major roads in Metro Manila

14°47′56″N 121°4′7″E / 14.79889°N 121.06861°E / 14.79889; 121.06861