The Río Nahualate (Spanish pronunciation: [nawaˈlate]) is a river in southwest Guatemala, originating in the Sierra Madre range, in the vicinity of Santa Catarina Ixtahuacán and Nahualá (Sololá). From there it flows southwards through the coastal lowlands of Suchitepéquez and Escuintla to the Pacific Ocean.

The Nahualate river basin covers a territory of 1,941 square kilometres (749 sq mi).