The Nana Barya River is a river in Central Africa. It arises in the west of the Central African Republic in the prefecture Ouham-Pendé and flows northeast, forming part of the international boundary between the Central African Republic and Chad. In Chad it flows into the Ouham River. The Nana Barya Faunal Reserve, a protected area in the Central African Republic, is named after this river.

• List of rivers of the Central African Republic