The Napaaktoktok River is a waterway in the Kitikmeot region of Nunavut in Canada. It flows generally north to Coronation Gulf, an arm of the Arctic Ocean. The Napaaktoktok runs parallel to the Coppermine River, 14.4 km (8.9 mi) to the west, and the Asiak River, 15.2 km (9.4 mi) to the east.

The community of Kugluktuk (formerly Coppermine) is located at the mouth of the Coppermine River, approximately 15.7 km (9.8 mi) to the west.

• List of rivers of Nunavut

67°49′02″N 114°44′11″W / 67.81722°N 114.73639°W / 67.81722; -114.73639 (Napaaktoktok River)