Neath Port Talbot Hospital (Welsh: Ysbyty Castell Nedd Port Talbot) is a general hospital located in Port Talbot, Wales. It is managed by Swansea Bay University Health Board.

The hospital, which was commissioned to replace Neath General Hospital and Port Talbot General Hospital, was procured under a Private Finance Initiative contract in May 2000. It was designed by SSL and built by Kier Group at a cost of £56 million; it was officially opened by the Prince of Wales on 3 February 2003.

In September 2012 the Health Board announced significant investment to create a new specialist IVF unit and expand the urology unit at the hospital in a bid to recruit and retain experienced clinicians.

In June 2023, a £21M expansion was completed which included three new theatres.

In May 2014 staff at the hospital was criticised in a report into the death of an elderly patient who had been treated at the hospital; the report found that there had been "variable or poor professional behaviour and practice in the care of frail older people".

• Official website
• Healthcare Inspectorate Wales inspection reports