Nebraska Highway 105 (N-105) is a 32.85-mile (52.87 km) state highway in Richardson, Pawnee, and Nemaha counties in Nebraska, United States. Its southern terminus is at an intersection with Nebraska Highway 8 south of Humboldt. Its northern terminus is at an intersection with Nebraska Highway 67 west of Brock.

Nebraska Highway 105 begins at an intersection with NE 8 south of Humboldt. It heads in a northbound direction through farmland, turning slightly to the northeast before entering Humboldt. At the north edge of the city, the highway meets with NE 4 and runs concurrently to the west for about 3.5 miles (5.6 km). At that point, NE 105 splits and heads directly to the north. It passes by NE 62 east of Elk Creek. Further north, it intersects with US 136 and runs concurrently northward for about a mile. NE 105 continues to the north near Johnson. To the north of Johnson, the highway meets its termination point at NE 67 west of Brock.

County	Location	mi	km	Destinations	Notes
Richardson	​	0.00	0.00	N-8 (555th Avenue)
	Humboldt	8.22	13.23	N-4 east	Southern end of N-4 concurrency
Richardson–Pawnee county line	​	11.69	18.81	N-4 west	Northern end of N-4 concurrency
Nemaha	​	18.69	30.08	N-62 west
	​	25.88	41.65	US 136 west	Southern end of US 136 concurrency
	​	26.73	43.02	US 136 east	Northern end of US 136 concurrency
	Johnson	27.84	44.80	S-64B east
	​	32.85	52.87	N-67
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

• List of state highways in Nebraska

• Nebraska Roads: NE 101-119