Nebraska Highway 43 (N-43) is a highway in southeastern Nebraska. It runs for a length of 30 miles (48 km) in a south-to-north direction. Its southern terminus is near Adams at an intersection with N-41. Its northern terminus is at an intersection with U.S. Highway 34 (US 34) in Eagle.

Nebraska Highway 43 begins near Adams at an intersection with N-41. The highway heads due north into farmland until Bennet. Shortly after Bennet, the highway meets N-2. N-2 and N-43 overlap until Palmyra, which is where N-43 turns north. N-43 goes north for four miles (6 km), west for one, and then north for three more miles, where it meets US 34 in Eagle and ends.

County	Location	mi	km	Destinations	Notes
Gage	​	0.00	0.00	N-41
Lancaster	Panama	9.01	14.50	S-55D west (Panama Road)
	​	17.07	27.47	N-2 west (Rokeby Road)	Interchange, southern end of N-2 overlap
Otoe	Palmyra	22.40	36.05	N-2 east	Northern end of N-2 overlap
Cass	Eagle	30.22	48.63	US 34 (East O Street)
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

• The Nebraska Highways Page: Highways 31 to 60
• Nebraska Roads: NE 41-60