Nebraska Highway 46 is a highway in Nebraska. It runs from south to north for a length of 12 miles (19 km). It has a southern terminus at Nebraska Highway 89 west of Stamford. It has a northern terminus at U.S. Highway 6 and U.S. Highway 34 north of Oxford.

Nebraska Highway 46 begins at Nebraska Highway 89 west of Stamford. It goes north and meets U.S. Highway 136 in Oxford. They overlap through Oxford and separate on the eastern edge of Oxford. After a brief northwesterly section, the highway turns north at the Furnas County/Harlan County border and ends when it meets U.S. 6 and U.S. 34 north of Oxford.

County	Location	mi	km	Destinations	Notes
Furnas	Stamford	0.00	0.00	N-89
	Oxford	7.46	12.01	US 136 west (Cornwall Street)	Southern end of US 136 overlap
Harlan		7.89	12.70	US 136 east	Northern end of US 136 overlap
Harlan–Furnas county line	​	12.00	19.31	US 6 / US 34
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

• Nebraska Roads: NE 41-60