Nebraska Highway 50 (N-50) is a north–south highway in the state of Nebraska. The southern terminus is at the Nebraska-Kansas border near Du Bois. The northern terminus is in the Millard neighborhood of Omaha at an intersection with U.S. Highway 275 (US 275) and N-92. It is a two lane highway except for the section from Springfield north to the southern edge of the Millard neighborhood in Omaha, which is a divided highway.

N-50 begins at the Kansas border south of Du Bois. The highway extends into Kansas as K-63. It runs through farmland, passes through Du Bois, and meets N-8. The two highways overlap, first by going north and then by going west, into Pawnee City. In Pawnee City, the overlap with N-8 ends and a new one with N-65 begins. The two highways overlap going north out of Pawnee City and separate near Table Rock, Nebraska. Two miles north, N-50 briefly overlaps N-4 before going north again. Near Elk Creek, N-50 meets N-62. Further north, N-50 passes through Tecumseh and meets U.S. Highway 136. The highway continues due north from Tecumseh through Syracuse, passing by N-41 and N-128 between Tecumseh and Syracuse. In Syracuse, N-50 meets N-2.

N-50 continues due north from Syracuse, meeting US 34 near Avoca. Near Manley, N-50 meets N-1. It continues north and curves northeast before meeting N-66. N-50 and N-66 overlap until the southwestern edge of Louisville, where they separate, though signage on N-50 has "To N-66" signs in the Louisville area, due to a gap in that highway in Louisville. After passing through Louisville, N-50 immediately crosses the Platte River and then immediately meets N-31. N-50 then goes northeast briefly and turns north to go through Springfield, where the highway becomes divided. As the highway approaches Omaha, it meets N-370 and then Interstate 80. It then continues north into the Millard neighborhood of Omaha on 144th Street, then turns northeast onto Millard Avenue. After passing through Millard, N-50 ends by meeting US 275 and N-92.

County	Location	mi	km	Destinations	Notes
40th parallel north		0.000	0.000	K-63 south / 702 Road (240th Road)	Nebraska–Kansas line; highway continues into Kansas as K-63
Pawnee	​	3.52	5.66	N-8 east – Boy Scout Camp, Falls City	South end of N-8 overlap
	Pawnee City	12.98	20.89	N-8 west / N-65 south (7th Street)	North end of N-8 overlap, south end of N-65 overlap
	​	16.50	26.55	N-65 north (713 Road) – Table Rock	North end of N-65 overlap
	​	18.57	29.89	N-4 east – Falls City	South end of N-4 overlap
	​	19.80	31.87	N-4 west – Beatrice, Burchard	North end of N-4 overlap
	​	20.79	33.46	S-67B west – Steinauer
Johnson	​	25.81	41.54	N-62 east – Elk Creek
	Tecumseh	32.82	52.82	US 136 (1st Street) – Beatrice, Auburn
	​	35.82	57.65	N-41 west – Wilber
	​	41.83	67.32	S-49A east – Cook
Otoe	​	43.82	70.52	S-66E west (R Road) – Burr
	​	47.81	76.94	N-128 east (N Road) – Lorton
	​	53.09	85.44	N-2 (Jerome and Betty Warner Expressway) – Lincoln, Nebraska City	Interchange
	​	56.82	91.44	S-66C east (E Road) – Otoe
Cass	​	62.82	101.10	US 34 (O Street) – Lincoln, Plattsmouth, Union
	​	66.80	107.50	S-13K east – Weeping Water
	​	69.82	112.36	N-1 – Murdock, Murray, Elwood
	​	70.32	113.17	S-13F east (Manley Road) – Manley
	Louisville	74.29	119.56	N-66 west (Park Highway) – South Bend	South end of N-66 overlap
		75.64	121.73	N-66 east (5th Street)	North end of N-66 overlap
	​	76.51	123.13	Walnut Street to N-66 east – Louisville, Plattsmouth
Sarpy	​	77.20	124.24	N-31 north (MoPac Trail) – Schramm Park
	Papillion	86.48	139.18	N-370 (Strategic Air Command Memorial Highway) – Gretna, Bellevue	Interchange
	Gretna	87.48	140.79	I-80 – Omaha, Lincoln	I-80 exit 440
Douglas	Omaha	91.45	147.17	132nd Street / US 275 / N-92 to I-80	Northern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

• Nebraska Roads: NE 41-60