Nebraska Highway 51 is a highway in eastern Nebraska. It has a length of 36.63 miles (58.95 km) and runs from west to east. It has a western terminus at U.S. Highway 275 northwest of Wisner and an eastern terminus at the Burt County Missouri River Bridge at the Missouri River in Decatur.

Nebraska Highway 51 begins northwest of Wisner at U.S. 275. It goes east into farmland and meets Nebraska Highway 9 west of Bancroft. It continues east and skirts the southern edge of Bancroft, after which it meets Nebraska Highway 16. After five miles (8 km), it meets U.S. Highway 77. It continues east and meets U.S. Highway 75 in Decatur. (According to a 1940 map, the highway turned south at Highway 77 to Lyons and then went east from Lyons to Decatur. It was apparently rerouted sometime between 1940 and 1955. The old section of road is now listed as Old Highway 118.) After overlapping in Decatur, Highway 51 turns east and crosses the Missouri River via the Burt County Missouri River Bridge. The highway continues on in Iowa as Iowa Highway 175.

County	Location	mi	km	Destinations	Notes
Cuming	Wisner	0.00	0.00	US 275 – West Point, Norfolk	Western terminus
	​	6.80	10.94	L-20A south (12th Road) to US 275 – Beemer
	​	11.78	18.96	N-9 (17th Road) – Pender, West Point
Cuming–Burt county line	​	19.75	31.78	N-16 north – Pender
Burt	​	24.50	39.43	US 77 – Sioux City, Fremont
	Decatur	35.50	57.13	US 75 south – Tekamah	Western end of US 75 overlap
		36.00	57.94	US 75 north (4th Avenue north)	Eastern end of US 75 overlap
Missouri River		36.63	58.95	Burt County Missouri River Bridge (formerly tolled) Nebraska–Iowa line
				Iowa 175 east	Continuation into Iowa
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

• Nebraska Roads: NE 41-60
• Nebraska Dept. of Roads Map Library