Niafunké Cercle is an administrative subdivision of the Tombouctou Region of Mali. The administrative center (chef-lieu) is the town of Niafunké. In the 2009 census the cercle had a population of 184,285. The Niger River runs for 100 km through the cercle.

The cercle is subdivided into eight communes:

• Banikane Narhawa
• Dianké
• Fittouga
• Koumaïra
• Léré
• N'Gorkou
• Soboundou
• Soumpi