Nister-Möhrendorf is an Ortsgemeinde – a community belonging to a Verbandsgemeinde – in the Westerwaldkreis in Rhineland-Palatinate, Germany.

The community lies in the Westerwald between Limburg and Siegen. Through the community flows the Große Nister. Nister-Möhrendorf belongs to the Verbandsgemeinde of Rennerod, a kind of collective municipality. Its seat is in the like-named town.

Both villages Nister and Möhrendorf had their first documentary mention in 1300. They were united in 1829.

At the latest since 1733, a mill had been in operation. Between 1820 and 1861, even two mills are listed in Nassau government records. The last miller ceased his work in 1959.

The municipal council is made up of 8 council members who were elected in a majority vote in a municipal election on June 9, 2024.

Running right through the community is Bundesstraße 414, leading from Herborn to Hachenburg. The nearest Autobahn interchange is Haiger/Burbach on the A 45 (Dortmund–Aschaffenburg), some 16 km away. The nearest InterCityExpress stop is the railway station at Montabaur on the Cologne-Frankfurt high-speed rail line.

In Nister-Möhrendorf, the primary school 'Hoher Westerwald' and a kindergarten are located.

• Nister-Möhrendorf in the collective municipality’s Web pages (in German)