North Penn High School is a part of the North Penn School District and is located in Towamencin Township, Pennsylvania, about a mile outside of Lansdale, Pennsylvania and 25 miles northwest of Philadelphia, on Valley Forge Road, also known as Pennsylvania Route 363.

North Penn High School was created in 1955 as the result of a consolidation of seven school districts in Montgomery County (Hatfield Joint Consolidated, Lansdale Borough, Line Lexington Independent, Montgomery Township, North Wales Borough, Towamencin Township and Upper Gwynedd Township) to educate students from three former high schools: Hatfield High School, Lansdale High School, and North Wales High School.

The original North Penn High School building was an expansion of the building that had served as Lansdale High School since the 1930s. The former Hatfield and North Wales buildings were eventually converted to elementary schools. The North Wales building is still used for this purpose today. The Hatfield building, later renamed the E.B. Laudenslager Elementary School, was replaced by a newer building in 1971. The current North Penn High School was constructed in 1971 because of severe overcrowding at the original school. The former high school building, located on Penn Street in Lansdale, is now Penndale Middle School.

As of the 2021–22 school year, the school had an enrollment of 3,138 students and 214.8 classroom teachers (on an FTE basis), for a student–teacher ratio of 14.6:1. There were 785 students (25.0% of enrollment) eligible for free lunch and 50 (1.6% of students) eligible for reduced-cost lunch.

Sophomores, juniors, and seniors are represented at the high school. Freshmen, although commonly the first year of high school, only occasionally attend certain classes, and are regularly enrolled in one of these three middle schools: Penndale Middle School, Pennbrook Middle School, and Pennfield Middle School. The middle schools enroll grades 7–9, while the elementary schools enroll grades K–6.

In 2005, 2006, and 2007, Sports Illustrated distinguished North Penn as having the best athletic program in Pennsylvania, noting that the school has "won 45 state championships over the last 10 years" and "is a power in football and is also dominant in boys' swimming." The North Penn Football team won the 2003 AAAA State Championship with a 15-0 season record. The school is also prominent in boys' and girls' water polo, and boys' winter track, spring track, cross country, and more recently baseball and softball.

In 2023, North Penn's theatre department won exclusive rights in Pennsylvania to perform Frozen as performed on Broadway. This was a result of the "United States of Frozen" competition, which granted one high school in each state the materials to perform the show for the very first time.

• Matt Ammendola, former professional football player, Arizona Cardinals, New York Jets, and Houston Texans
• Andrew Bryniarski, film and television actor, Leatherface in the 2003 remake of The Texas Chainsaw Massacre
• Dan Campbell, lead vocalist of rock band The Wonder Years
• Jay Caufield, former professional hockey player, Minnesota North Stars, New York Rangers, and Pittsburgh Penguins
• Sharon Little, singer-songwriter
• Edwin Kneedler, former Deputy Solicitor General of the United States who has argued more U.S. Supreme Court cases than any other living person
• Steve Malagari, Pennsylvania State Representative, Pennsylvania House of Representatives, District 53
• Sean McDermott, head coach of the Buffalo Bills
• Brandon McManus, professional football player, Jacksonville Jaguars
• John Oates, rock musician, Hall & Oates
• Rozes, musician, singer, and songwriter
• Jennifer Strong, former U.S. women's national soccer team member
• Reece Udinski, former college football player
• Liza Weil, actress, Paris Geller on Gilmore Girls and Bonnie Winterbottom on How to Get Away with Murder

• North Penn High School Website