North Santee is a census-designated place (CDP) in Clarendon County, South Carolina, United States. It was first listed as a CDP prior to the 2020 census with a population of 749.

The CDP is on the southwestern edge of Clarendon County, on the northeast shore of Lake Marion, a reservoir on the Santee River. Interstate 95 crosses Lake Marion at North Santee, with access from Exit 102. U.S. Routes 15 and 301 pass through the CDP as a surface highway, joining I-95 at Exit 102 to cross the lake. Summerton is 7 miles (11 km) to the northeast, and Santee is 5 miles (8 km) to the southwest in Orangeburg County.

Santee Indian Mound and Fort Watson is a historic site in the north part of the CDP, near the shore of Lake Marion.

Historical population

Census	Pop.	Note	%±
2020	749		—
U.S. Decennial Census 2020

North Santee CDP, South Carolina – Demographic Profile
(NH = Non-Hispanic)

Race / Ethnicity	Pop 2020	% 2020
White alone (NH)	639	85.31%
Black or African American alone (NH)	79	10.55%
Native American or Alaska Native alone (NH)	0	0.00%
Asian alone (NH)	3	0.40%
Pacific Islander alone (NH)	0	0.00%
Some Other Race alone (NH)	0	0.00%
Mixed Race/Multi-Racial (NH)	20	2.67%
Hispanic or Latino (any race)	8	1.07%
Total	749	100.00%

Note: the US Census treats Hispanic/Latino as an ethnic category. This table excludes Latinos from the racial categories and assigns them to a separate category. Hispanics/Latinos can be of any race.

It is in Clarendon School District 1.