• Axl Rose – lead vocals, piano, whistle, whistling
• Slash – lead guitar, rhythm guitar, talkbox, slide guitar
• Duff McKagan – bass, backing vocals, lead vocals on Attitude cover
• Dizzy Reed – keyboards, piano, percussion, backing vocals
• Richard Fortus – rhythm guitar, lead guitar, backing vocals
• Frank Ferrer – drums, percussion
• Melissa Reese – keyboards, synthesizers, sub-bass, percussion, backing vocals

• Sebastian Bach (performed "My Michelle" during the concert of April 9, 2016.)
• Angus Young (performed "Whole Lotta Rosie" and/or "Riff Raff" during the April 16, 2016, February 10, 11, 14, June 22 and concert of July 12, 2017.)
• Steven Adler (performed "Out Ta Get Me" and/or "My Michelle" during the July 6, 9, August 19, November 4 and concert of November 5, 2016.)
• Angry Anderson (performed "Nice Boys" during the concert of February 11, 2017.)
• P!nk (performed "Patience" during the concert of October 11, 2017.)
• Billy Gibbons (performed "Patience" during the concert of November 10, 2017.)
• Dave Grohl (performed "Paradise City" during the concert of November 14, 2017.)

On April 8, 2016, before the first show at T-Mobile Arena in Las Vegas, Guns N' Roses posted a video in social media showing a recap of the event at the former Tower Records building and concert at the Troubadour in West Hollywood that took place a week earlier, on April 1. The three-minute video showed cuts from different songs played at the concert, as well as a time-lapse of the set-up of the Guns N' Roses museum that was temporarily placed inside the Tower Records building. Small snippets with comments from fans outside the museum was also featured in the clip.

The Coachella Festival had a live internet broadcast via YouTube of select performances during the first weekend of the festival. The Guns N' Roses concert was not shown in its entirety, but rather two songs from the set, namely "Welcome to the Jungle" and "November Rain". During the second weekend of the festival there was a 360° live feed from the festival, and again two songs from the Guns N' Roses set were selected for broadcast. This time they showed "November Rain" and "Knockin' on Heaven's Door".

A concert held at the Apollo Theater in New York City on July 20, 2017, was broadcast live in its entirety on SiriusXM satellite radio. The concert was an invite-only event where subscribers to the satellite radio service were eligible to win tickets. Similarly, the final show of the North American leg in 2017 in Inglewood, CA on November 29 was also broadcast on SiriusXM.

The first leg of the tour featured sold-out shows in West Hollywood, Las Vegas and Mexico City grossing a total of $15.5 million. In addition Guns N' Roses headlined one day each weekend of the Coachella Festival earning an unknown figure. On June 23, 2016, the second leg of the tour started, featuring stadiums in the United States as well as one show in Toronto, Ontario, Canada. The box office numbers reported for the leg added up to $116.8 million, with 12 of the total 25 performances being sold-out shows. The Latin American leg yielded up to a total gross of $56.5 million with more than 565,000 tickets sold. They played 13 shows in 11 cities, selling out 8 of them. By the end of 2016 the band had played for over 1.8 million people and grossed $192 million. The 2017 European and North American legs of the tour sold one million tickets just 24 hours after going on sale in late 2016. The tour was the highest earning per-city concert tour in 2016, making $5.5 million per show, as well as the fourth highest-grossing tour of 2016.

Additionally, the tour was the second highest grossing North American Tour (the highest grossing of any band) for 2016, grossing $130.8 million in North America. The shows at MetLife Stadium on July 23 and 24 were ranked as the 9th highest grossing of the year by Pollstar, earning a combined $11.2 million. In Australia and New Zealand, the sold-out shows amounted to over 350,000 tickets. During the first half of 2017 dates have grossed a total of $151.5 million, while the single biggest concert gross of the year, so far, is Guns N' Roses' London Stadium shows which sold 139,000 tickets and grossed $17.3 million over two nights. The tour has of now surpassed $480 million in gross revenue.

The tour was honored at the Billboard Touring Awards in November 2017, winning Top Tour/Top Draw and being nominated for Top Boxscore. The Tour was also nominated for Top Rock Tour at the 2017 Billboard Music Awards, with the band being nominated for Top Touring Artist and Top Duo/Group as well. In 2018, they were nominated for Top Touring artist and Top Rock Tour. The band also received the inaugural Ticketmaster Touring Milestone Award in 2019.

The tour wrapped up after 158 concerts with $584.2 million grossed and 5,371,891 tickets sold. It became third highest-grossing tour in the history of Billboard's Boxscore.

Alice in Chains was the first band announced as an opening act on the tour. They played both of the Las Vegas shows in April 2016, while returning for select dates during the following summer leg of North America. Duff McKagan has ties with the band as he toured with them in 2006 and also expressing interest in writing a biography on them. Another band with previous ties with Guns N' Roses was selected for the Mexican dates in April – The Cult. As part of their Appetite for Destruction Tour, Guns N' Roses opened for The Cult for a whole North American leg in August and September 1987. A later drummer of The Cult, Matt Sorum, would eventually join Guns N' Roses in 1990 and stay until 1997. The Cult also returned to support the band during the summer of 2016.

Tyler Bryant & the Shakedown were selected for numerous dates both in North America and Singapore. Before opening for Guns N' Roses they had been the opening band for AC/DC during the European leg of their Rock or Bust Tour in which Axl Rose served as the replacement singer. Chris Stapleton was a surprising selection as opener for the Nashville show, as Guns N' Roses usually picks artists within the same music genre as themselves, though it proved a successful choice for the Tennessee audience. Wolfmother opened their first show on the tour on July 12 in Pittsburgh, and would continue to appear as a supporting act throughout the tour. The singer, Andrew Stockdale, has a past working relationship with Slash, appearing on the 2010 single "By The Sword" from Slash's first solo album.

Canadian punk rock band Billy Talent opened the only Canada date in Toronto during the summer North American leg of the tour. For the two double shows in Foxborough and East Rutherford, long-time friend of the band Lenny Kravitz was the supporting act. Slash has recorded with Kravitz in the past, notably the first single from the album Mama Said, "Always on the Run". Kravitz has also appeared on stage with Guns N' Roses before, during the June 6, 1992 Use Your Illusion Tour stop in Paris, France, where they played the single live. The guitarist/singer was also spotted in the audience of Guns N' Roses' April 1 surprise show at the Troubadour, where he said that he had re-connected with the band.

Another unusual choice as opening act was Skrillex, who performed in Houston, Texas on August 5. British band The Struts was handpicked to open the show in San Francisco on August 9. Similarly to Guns N' Roses, the band lists Queen and The Rolling Stones as influences on their music. At McKagan's homecoming show in Seattle on August 12, his daughter Grace's band The Pink Slips opened the event alongside Alice in Chains. Zakk Wylde has ties to Guns N' Roses back to 1995 when he was in the studio with the band. He was chosen as opener on the show of August 15. Wylde had also previously played as a guest with Guns N' Roses on stage back in 2011, where he also performed as an opening act with his band Black Label Society.

For the Latin American leg of the tour, openings acts were usually regionally-based bands, including Plebe Rude, Airbag, and Massacre, among others. Marky Ramone and Tyler Bryant & the Shakedown also opened shows. Leg 4 of the tour saw most shows opened up by Wolfmother and/or Rose Tattoo, and Man with a Mission and Babymetal also opened shows.

Leg 5 saw support from Royal Blood, The Darkness, Mark Lanegan, Phil Campbell & The Bastard Sons, The Kills, Virgin, Killing Joke, Biffy Clyro, and Backyard Babies. Michael Monroe also supported, as well as Wolfmother and Tyler Bryant & the Shakedown.

Leg 6 featured Deftones, Sturgill Simpson, Live, Our Lady Peace, ZZ Top, The Kills and Royal Blood opening for the band. On Leg 7, The Who joined the band as co-headliners.

The eighth leg of the tour did not feature any opening acts, allowing the band to play earlier. Leg 9 of the tour featured returning opening act Tyler Bryant & the Shakedown, and new opening acts such as Volbeat, Gojira, Nothing More The Dead Daisies (a band Richard Fortus, Frank Ferrer and Dizzy Reed were previously a part of) Jonathan Davis of Korn, Ghost, Graveyard, Rival Sons Manic Street Preachers, Greta Van Fleet, Russian band Other Noises, and The Pink Slips

Planning and preparation for the tour started in January 2016. TAIT Towers was brought in by long time client production manager Dale "Opie" Skjerseth to produce the stage and show itself. They have previously built and designed world tours with artists such as The Rolling Stones, Bon Jovi, U2, Madonna, and Taylor Swift.The set was designed by Phil Ealy, previously the light designer on the Use Your Illusion tour. They built a 71-foot (22 m) wide main stage including band risers, LED staircases made with P9 LED video tiles, LED fascia and amp stacks, and a self-climber piano lift used for Rose's performance of "November Rain." Additionally, they developed an 80-foot (24 m) automated video track truss system installed with power transmission units to automate Screenworks background video screens. TAIT Navigator, a proprietary automation platform, operated and controlled the self-climber piano lift as well as automated Screenworks' video screens into variations of three to six columns.

The stage had staircases on each side as well as in the middle, leading up to the drum-kit. There was a walkway extending all the way around the drummer and two keyboardists, with staircases implemented into the riser, allowing the band members to freely move up amongst the keyboardists and the drummer during the show. At the center of the stage, there was a catwalk extending 28 feet (9 m) into the audience pit area hosting the self-climber piano lift. This catwalk was not assembled for the first seven shows as a result of Rose's foot injury and he was subsequently forced to have a seat on the main stage instead. An extensive lighting rig was assembled in the center stage area which featured Atomic 3000 LED and MAC III AirFX fixtures by Martin. The band members wanted a stage show experience similar to their Use Your Illusion tour, with updated technology. Each side of the stage had big LED video screens, primarily used to show close-ups of the band during the show. Roughly 250 professional and local crew members (125 of each) were needed to set up the staging, speakers and video boards. The setup process took three days and more than 20 production trucks to transfer from each city. Additionally there were three fleets of 16 steel trucks each, carrying the skeleton of the stage, making them able to set up the basis of the stage in three different venues at any time.

Motion graphics agency Creative Works London were brought back to do the visuals package for the stage show after having worked on the 2014 tours of South America and the Las Vegas residency. The new footage and graphics included familiar elements associated with many of the songs, like animations of old-school TV sets with the band members' skull drawings made famous by the cover of the Appetite For Destruction album. The TV sets were a throwback to the "Welcome to the Jungle" music video. "You Could Be Mine" graphics consisted of the band stylized as a resemblance to Terminators, influenced by the song having been used as the soundtrack on the Terminator 2: Judgment Day movie and original music video. Elements from the Chinese Democracy alternative art series were used in songs such as "Chinese Democracy" and "Catcher in the Rye". A set of changing backgrounds with rain and rose petals featured during "November Rain", whilst a black crow inspired from the official music video, was made to fly across the screens during "Don't Cry". Slash's signature skull with a top-hat, smoking a cigarette, was displayed on the main screen during his solo performance of "The Godfather theme", with a similar skull graphic during Duff's vocal performance. Pyrotechnics were used throughout the set, for a selection of songs.

The intro to the show featured either the classic Guns N' Roses bullet-logo made to look like a neon sign, blinking on the big screen on center stage, or an animated bullet-logo with the revolvers firing shots. The "Looney Tunes" intro theme played, and then the whole venue went dark with the theme from The Equalizer playing over the PA system for a few minutes before the band then started the first song of the set. The show ended with a considerable amount of pyrotechnics on stage, and confetti was shot out over the crowd during the ending of "Paradise City". When they played outdoor venues, an extensive fireworks display was added.

As this was a semi-reunion of the "classic line-up" of Guns N' Roses, many were curious about which songs they would play at the concerts: fans speculated widely if they would add songs from the Use Your Illusion albums to their setlist, and if they would continue to play songs from their latest release, the 2008 album Chinese Democracy – which Slash and McKagan were not a part of creating or recording. McKagan had previously performed songs from Chinese Democracy with Guns N' Roses in 2014, when he stepped in as a substitute for Tommy Stinson while he was busy playing shows with The Replacements. After the first show – the surprise performance at the Troubadour – some questions were answered. They did bring back "Double Talkin' Jive" from Use Your Illusion I, while they also played tracks from Chinese Democracy, "Chinese Democracy" and "Better". This development continued at the first arena-sized show at T-Mobile Arena in Las Vegas where they further extended the setlist with songs like "Coma" and "This I Love", where the former had not been performed by the band since 1993. "The Godfather theme", which used to be a staple Slash solo number during past tours, was also brought back into the set. A few shows into the first leg, during the second show in Mexico City, they debuted "There Was a Time", another song from the Chinese Democracy album. "Sorry" and "Catcher in the Rye" were later debuted during shows in July. It is also notable that Slash had altered some guitar parts of the songs from this album. On June 3, 2018, the band debuted their cover of Velvet Revolver's Slither, which Slash and McKagan created when they were in the group. While Slash and McKagan had played the song regularly since leaving Velvet Revolver, this was the first time Guns N' Roses had performed it, and the first time Axl Rose had sung it. In a 2018 interview with Eddie Trunk, Slash revealed that they had rehearsed the song very early on in the tour, but simply didn't play it at any concerts up until it was debuted. The song has since become a regular in the setlist, having been played at every 2018, 2019, and 2020 Guns N' Roses performance. On June 6, 2018, the band performed Shadow Of Your Love, which had not been played since 1987. In the same Eddie Trunk interview, Slash revealed that releasing the song as a single and as part of the Appetite For Destruction "Locked N' Loaded" Box Set was what made them want to start playing it live again. While not played at every show, it was often played at Guns N' Roses performances from 2018 onward. On October 7, 2019, Guns N' Roses performed the Use Your Illusion II track Locomotive, which had not been played live since 1992. Each time it was played, it replaced Coma as a lead-in to band member introductions and Slash's Guitar Solo. The song was played two more times on the tour: October 13 and 23, 2019. On October 23, 2019, the band played Dead Horse, which Guns N' Roses had not played since 1993, although Duff McKagan had performed it as a solo act the previous summer. The band played it at every remaining show of the tour, and continued to include it in their 2020 performances.

The band continued, as they had done in past tours, to keep the core set which included their most well-known songs. The core set largely consisted of songs from their debut album Appetite For Destruction, namely "Welcome to the Jungle", "It's So Easy", "Nightrain", "Mr. Brownstone", "Paradise City", "Sweet Child o' Mine" and "Rocket Queen". The remaining core songs were tracks from the Use Your Illusion albums and Chinese Democracy. This included some of the aforementioned songs: the newly added "Double Talkin' Jive", as well as "Chinese Democracy", "Better" and "This I Love". In addition, "Live and Let Die", "November Rain", "Knockin' On Heaven's Door", "Estranged", and "You Could Be Mine" were played at every concert (except "November Rain" and "Estranged", which were not played at the shorter club show at the Troubadour).

In all tours from 2001 and on, Guns N' Roses had (with few exceptions) opened their show with either "Welcome to the Jungle" or "Chinese Democracy". For this tour, they changed things up, using the song "It's So Easy" as the opening song. "Chinese Democracy" and "Welcome to the Jungle" took the number 3 and 4 spots in the set, with "Mr. Brownstone" being the second song played, as was common during their older tours.

In past tours, an extensive number of solo spots were a usual part of the setlist. They cut this down to a minimum, keeping the set quite tight with the performance of regular songs as the main focus. Slash did have a solo spot with "The Godfather theme", a guitar instrumental piece with the rest of the band backing up and functioning as a lead-in to "Sweet Child o' Mine". As a second new addition, Fortus and Slash were doing a guitar instrumental version of the Pink Floyd song "Wish You Were Here", which worked as a prelude to "November Rain". McKagan took the lead vocals during a regular spot in the set, singing a song from the Guns N' Roses punk cover album "The Spaghetti Incident?". From show to show, he alternated between "New Rose" – the debut single of the British punk rock group The Damned, "Raw Power" – a song by Iggy Pop and the Stooges which he had previously performed at some of the Guns N' Roses shows in 2014, and "Attitude" – a Misfits song he played regularly on the Use Your Illusion Tour and in 2014.

The band ended their concerts with the song "Paradise City", but the total length of the encore set varied. The songs included in this set, with the exception of "Paradise City", were different ones from show to show, including "The Seeker", "Patience", "Don't Cry", "Yesterdays", "Used To Love Her", "Catcher In The Rye" and "Sorry" in various combinations.

This set list was taken from the September 6, 2017 concert in El Paso, Texas. It does not represent all shows throughout the tour.

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