Nowa Sarzyna (Polish: [ˈnɔva saˈʐɨna]; Ukrainian: Но́ва Сажи́на, romanized: Nóva Sazhýna) is a town in Poland, with 5,970 inhabitants as of 2017.

The first buildings of Nowa Sarzyna were constructed in the late 1930s to house workers of a new chemical plant, built as part of Poland's Central Industrial Region. The town lies on land formerly belonging to the village Sarzyna. City rights were granted in 1973. The chemical plant function as Zakłady Chemiczne "Organika-Sarzyna" S.A. and is the town's largest employing industry.

The area of the Nowa Sarzyna commune was covered by a forest, later known as the Sandomierz Forest. The first traces of settlement along the sandy banks of the San River date back to the Neolithic period (around 4500 BC), with early settlers being nomadic hunters. During the Bronze Age, the region was inhabited by Proto-Slavs associated with the Lusatian culture's Tarnobrzeg group. Roman-era coins found in Leżajsk suggest the existence of a trade route passing through the area.

Settlement in the southeastern part of the Sandomierz Forest revived in the 14th and 15th centuries, coinciding with the development of a water trade route along the San River. Inhabitants were primarily of Ruthenian origin, and the region became a natural border between Poland and Ruthenia, leading to frequent disputes. A period of relative peace began in 1340, when Casimir the Great annexed Galicia and Ruthenia to Poland. The area became part of royal estates, and German law was introduced for the establishment of service settlements, including Sarzyna, founded in 1390. According to tradition, 24 farmers were tasked with clearing and cultivating 100 acres of forest each. From 1433, Sarzyna was leased to Spytek from Tarnów, the Sandomierz voivode.

The village's location in the forest influenced the occupations of its population, who were primarily engaged in forestry, beekeeping, and iron smelting. In 1565, iron production began in what is now Ruda Łańcucka, marking an early industrial activity in the area. The first church in Sarzyna was built in 1595, and the village became a Roman Catholic parish in 1598.

During the 16th and 17th centuries, Sarzyna faced repeated invasions. The first major attack was a Tatar invasion in 1524, followed by conflicts between local lords and the Tatars in the 17th century. These invasions severely impacted the local economy. After the first partition of Poland in 1772, Sarzyna became part of Austrian-controlled Galicia, where a systematic colonization policy led to the establishment of German colonies.

In the 19th century, Sarzyna's development was influenced by figures such as Father Marceli Śleczkowski, a parish priest who was a member of the Literary Society in Kraków and involved in the canonization of St. Józef Kuncewicz. In 1840, Baron Wilhelm Hompesch, an Austrian magnate, bought nearby Łętownia, and under his son Ferdynand, a railway line from Rozwadów to Przeworsk was constructed.

The outbreak of World War I caused significant damage to Sarzyna, with the village suffering from fighting and fire. After the war, Sarzyna's residents faced economic challenges, with less fertile lands leading to the growth of basketry as a secondary industry. The area's development accelerated in 1937 with the construction of chemical plants as part of the Central Industrial District (COP), initiated by Deputy Minister Eugeniusz Kwiatkowski. However, this growth was interrupted by the outbreak of World War II. German troops occupied the factory, dismantling its equipment and forcing local labor. Resistance movements, such as the Home Army and Peasant Battalions, were active in the region, but reprisals by the Germans included the execution of civilians.

Following the war, Sarzyna's infrastructure was severely damaged, including the destruction of the factory and surrounding areas. After the Russian entry in July 1944, the factory was cleared of remnants of war, and management was eventually taken over by the Boruta Chemical Plant in Zgierz.