Odeonsplatz is an important U-Bahn interchange station on the northern edge of Munich's Old Town. It is serviced by the , and , lines of the Munich U-Bahn system, with U 4 and U 5 running in an east-west direction and U3, U6 running perpendicular in a north-south direction. It is one of the Old Town's principal U-Bahn interchanges, the others being Sendlinger Tor on the southern periphery, Karlsplatz in the west and Marienplatz in the city centre.

The station is also serviced by the Museumsline 100, a bus line that calls at several important museums throughout town. Moreover, the night service N40 calls at Odeonsplatz.