State Route 60 (SR 60) is a north–south state highway that runs the entire length of the U.S. state of Ohio, from the Williamstown Bridge over the Ohio River in Marietta to U.S. Route 6 (US 6) near Lake Erie in Vermilion. It is the seventh longest state route in Ohio.

Heading south from Vermilion, SR 60 traverses rural North Central Ohio while connecting Vermilion, New London, Ashland, and Loudonville. South of Loudonville, SR 60 enters more hilly country, before entering the Muskingum River Valley at Dresden. It closely parallels the Muskingum River for the remainder of its journey to Marietta except for an eleven-mile (18 km) stretch in Morgan County where it moves inland to avoid bends in the river.

Markers for SR 60 are not posted south of the Greene Street/3rd Street intersection in Marietta, the location of SR 26's southern terminus. SR 60 is unsigned along SR 7 / SR 26 / Greene Street and the Williamstown Bridge approach.

Parts of SR 60 were once signed as SR 77. In order to eliminate a numerical duplication with an Interstate highway in Ohio having the same number, Interstate 77, SR 77 was renumbered in part as SR 60.

County	Location	mi	km	Destinations	Notes
Wood	Williamstown			WV 31 south – Williamstown	Continuation into West Virginia
Ohio River		0.00	0.00	Williamstown Bridge
Washington	Marietta	0.28	0.45	SR 7 north (Greene Street) – Matamoras	Southern end of SR 7 concurrency
		1.32	2.12	SR 7 south (Washington Street) – Belpre, Athens	Northern end of SR 7 concurrency
	Muskingum Township	3.58	5.76	SR 821 north to I-77 – Lower Salem	Southern terminus of SR 821
	Lowell	10.65	17.14	SR 530 east (Walnut Street) – Warner	Western terminus of SR 530
	Beverly	20.26	32.61	SR 339 north (Center Street) – Dexter City	Southern end of SR 339 concurrency
		20.44	32.89	SR 339 south (Ferry Street) – Porterfield	Northern end of SR 339 concurrency
	Waterford Township	22.15	35.65	SR 83 north – Cumberland	Southern terminus of SR 83
Morgan	Center Township	25.59	41.18	SR 266 west – Stockport	Eastern terminus of SR 266
	Morgan Township	34.06	54.81	SR 607 north (Monastery Road)	Southern terminus of SR 607
	McConnelsville	35.65	57.37	SR 376 south (10th Street) – Stockport	Southern end of SR 376 concurrency
		35.85	57.69	SR 78 east (7th Street) – Caldwell	Southern end of SR 78 concurrency
		35.92	57.81	SR 376 north (Kennebec Avenue)	Northern end of SR 376 concurrency
		36.47	58.69	SR 37 west / SR 78 west – Malta, Glouster, New Lexington	Northern end of SR 78 concurrency; eastern terminus of SR 37
Muskingum	Blue Rock Township	49.08	78.99	SR 376 south / CR 66 – Ruraldale	Northern terminus of SR 376
	Wayne Township	60.53	97.41	SR 555 south to SR 719 / US 22 west / SR 93 south – South Zanesville	Northern terminus of SR 555
	Zanesville	62.30	100.26	SR 146 east (Marietta Street)	Southern end of SR 146 concurrency
		62.56	100.68	US 22 west / US 40 west / SR 93 south (Main Street)	Southern end of US 22 / US 40 / SR 93 concurrency
		62.62	100.78	US 22 east / US 40 east / SR 93 north (Greenwood Avenue)	Northern end of US 22 / US 40 / SR 93 concurrency
		62.86– 62.91	101.16– 101.24	I-70 / Elm Street – Wheeling, W.Va., Columbus	Exit 155 (I-70)
		63.11	101.57	SR 666 north (Zane Street)	Southern terminus of SR 666
		63.85	102.76	SR 60G south / SR 146 east (Adair Avenue) / Maple Avenue	Northern terminus of unsigned SR 60G; northern end of SR 146 concurrency
	Dresden	78.30	126.01	SR 208 east (Ninth Street) – Adamsville	Western terminus of SR 208
	Cass Township	80.96– 81.10	130.29– 130.52	SR 16 – Coshocton, Newark	Interchange
Coshocton	Bedford Township	89.01	143.25	SR 541 west – Martinsburg	Southern end of SR 541 concurrency
		89.14	143.46	SR 541 east – Coshocton	Northern end of SR 541 concurrency
	Warsaw	96.04	154.56	US 36 west (Main Street) / Bridge Street – Nellie	Southern end of US 36 concurrency
	Bethlehem Township	98.55	158.60	US 36 east – Coshocton	Northern end of US 36 concurrency
Holmes	Killbuck Township	112.50	181.05	US 62 – Brinkhaven, Millersburg
	Monroe Township	119.85	192.88	SR 39 east / SR 754 north – Millersburg, Shreve	Southern end of SR 39 concurrency; southern terminus of SR 754
	Nashville	124.97	201.12	SR 514 (Wooster Street)
	Washington Township	125.71	202.31	SR 179 north / Township Road 477 – Mohicanville	Southern terminus of SR 179
Ashland	Loudonville	131.94	212.34	SR 3 south / SR 39 west (East Main Street) / South Union Street – Mount Vernon, Mohican	Northern end of SR 39 concurrency; southern end of SR 3 concurrency
		132.11	212.61	SR 3 north (Washington Street) – Wooster	Northern end of SR 3 concurrency
	Green Township	137.02	220.51	SR 95 – Perrysville, Mohicanville
	Hayesville	142.21	228.86	SR 179 south (Main Street)	Northern terminus of SR 179
	Vermillion Township	142.98– 143.14	230.10– 230.36	US 30 – Wooster, Mansfield	Interchange
	Ashland	147.82	237.89	SR 511 south to US 42	Southern end of SR 511 concurrency
		149.69	240.90	SR 96 east (East Main Street) / Center Street	Southern end of SR 96 concurrency
		149.88	241.21	SR 96 west (Sandusky Street) / W 2nd Street	Northern end of SR 96 concurrency
		150.54	242.27	SR 511 north (West 13th Street)	Northern end of SR 511 concurrency
		151.22	243.36	US 250 east / Faultless Drive – Wooster	Southern end of US 250 concurrency
	Savannah	156.76	252.28	SR 302 east / McClaine Street – Nankin	Western terminus of SR 302
		157.10	252.83	SR 545 south (Crowell Street) / CR 620 (Robinson Street) – Olivesburg, Mansfield	Northern terminus of SR 545
	Clear Creek Township	157.66	253.73	US 250 west – Norwalk	Northern end of US 250 concurrency
	Ruggles Township	161.75	260.31	US 224 – Tiffin, Lodi
Huron	New London	165.63	266.56	SR 162 (Main Street)
	Clarksfield Township	172.74	278.00	SR 18 east – Wellington	Southern end of SR 18 concurrency
		173.33	278.95	SR 18 west – Norwalk	Northern end of SR 18 concurrency
	Wakeman–Wakeman Township municipal line	177.19	285.16	SR 303 (Townsend Street)
	Wakeman	177.70	285.98	US 20 west (Main Street) / Railroad Street – Norwalk	Southern end of US 20 concurrency
		177.83	286.19	US 20 east (East Main Street) – Elyria	Northern end of US 20 concurrency
Erie	Florence Township	183.65	295.56	SR 113 – Milan, Elyria
	Vermilion Township	188.23– 188.51	302.93– 303.38	I-90 / SR 2 – Sandusky, Cleveland	Interchange
	Vermilion	190.08	305.90	US 6 / LECT (Liberty Avenue) / Main Street
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

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