State Route 61 (SR 61) is a north–south state highway in the northern portion of the U.S. state of Ohio. Its southern terminus is at the U.S. Route 36/State Route 3 concurrency in Sunbury, and its northern terminus is at U.S. Route 6 east of Huron, at the southernmost point of Lake Erie (which is subsequently the southernmost northern border of the United States). State Route 61 is routed through the communities of Mount Gilead, Galion, Crestline, Shelby, Plymouth, Norwalk, and Berlin Heights.

County	Location	mi	km	Destinations	Notes
Delaware	Sunbury	0.00	0.00	US 36 west / SR 37 (Cherry Street) to I-71 / SR 3 south (State Street) – Delaware	Southern end of US 36 / SR 3 concurrency
	Berkshire Township	0.43	0.69	US 36 east / SR 3 north / Columbus Street – Mount Vernon	Northern end of US 36 / SR 3 concurrency
	Kingston Township	4.77	7.68	SR 656 north / Wilson Road	Southern terminus of SR 656
		5.45	8.77	SR 521 – Delaware, Olive Green
Morrow	Bennington Township	9.18– 9.36	14.77– 15.06	I-71 – Cleveland, Columbus	Exit 140 (I-71)
		11.11	17.88	SR 229 – Ashley, Marengo, Mount Vernon
	Lincoln Township	16.68	26.84	SR 529 west / CR 23 – Cardington	Eastern terminus of SR 529
	Gilead Township	21.01	33.81	US 42 south – Delaware	Southern end of US 42 concurrency
	Mount Gilead	21.61	34.78	SR 95A (Marion Street)
		21.74	34.99	SR 95 (High Street)
		21.97	35.36	US 42 north (Union Street) – Mansfield	Northern end of US 42 concurrency
	Washington Township	30.70	49.41	SR 288 – Marion, Lexington
		31.01	49.91	SR 309 west – Marion	Southern end of SR 309 concurrency
Crawford	Galion	34.71	55.86	SR 19 west (Harding Way) / SR 598 north (Portland Way)	Western end of SR 19 concurrency; southern terminus of SR 598
		35.98	57.90	SR 19 east / SR 97 east (Harding Way) / East Street	Eastern end of SR 19 concurrency; western terminus of SR 97
		38.08	61.28	SR 309 east – Ontario	Northern end of SR 309 concurrency
	Galion–Crestline municipal line	39.20– 39.34	63.09– 63.31	US 30 – Mansfield, Bucyrus	Interchange
	Crestline	41.32	66.50	SR 181 east (Main Street) / Seltzer Street	Western terminus of SR 181
Richland	Sharon Township	49.01	78.87	SR 314 south – Chesterville	Northern terminus of SR 314
	Shelby	51.17	82.35	SR 39 / SR 96 (West Main Street)
	Plymouth	58.72	94.50	SR 98 south (Bucyrus Street)	Southern end of SR 98 concurrency
Richland–Huron county line		59.25	95.35	SR 98 ends / SR 603 south (Baseline Road)	Northern end of SR 98 concurrency; northern terminus of SR 603
Huron	New Haven Township	61.77	99.41	SR 598 south	Southern end of SR 598 concurrency
		61.90	99.62	US 224 – Greenwich, Tiffin
		62.16	100.04	SR 598 north / North Street	Northern end of SR 598 concurrency
		63.74	102.58	SR 103 west / Boughtonville Road – Willard	Eastern terminus of SR 103
	Greenfield Township	67.39	108.45	SR 162 – Steuben, North Fairfield
	Norwalk	76.70	123.44	SR 61C to US 20 west / SR 18 west – Toledo	Eastern terminus of unsigned SR 61C
		78.04	125.59	US 250 / SR 13 (Whittlesey Avenue)
	Norwalk Township	81.21	130.69	SR 601 – Milan
Erie	Berlin Township	84.91	136.65	SR 113 west – Milan	Southern end of SR 113 concurrency
	Berlin Heights–Berlin Township municipal line	86.09	138.55	SR 113 east / CR 58 (Ceylon Road) – Elyria	Northern end of SR 113 concurrency
	Berlin Township	90.38– 90.51	145.45– 145.66	I-90 / SR 2 – Sandusky, Cleveland	Interchange
		91.16	146.71	US 6 / LECT – Sandusky, Cleveland
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

State Route 61C (SR 61C) is a 0.72-mile-long (1.16 km) connection between the Norwalk Bypass US 20/SR 18 and SR 61 southwest of Norwalk. The intersection forms a sideways triangle with SR 61 as the base on the east, US 20 as the south side, and Route 61C as the north side. SR 61C exists because US 20 bridges SR 61 on the south side of the triangle and would have not intersected SR 61 otherwise. SR 61C is part of a former alignment of US 20.