The Old Vicksburg Bridge, also known as Mississippi River Bridge, is a cantilever bridge carrying one rail line across the Mississippi River between Delta, Louisiana and Vicksburg, Mississippi.

It was listed on the National Register of Historic Places in 1989.

It was built by the Vicksburg Bridge & Terminal Co. during 1928-1930 and has three cantilevered truss spans and three Parker truss spans.

Until 1998, the bridge was open to motor vehicles and carried U.S. Route 80 (US 80) across the Mississippi River. It is now only a railroad bridge, though one road lane runs through the bridge for inspection by workers. It was replaced by the new Vicksburg Bridge, a short distance down river, for vehicle crossings. During this period, a rather unusual system was used to accommodate tractor-trailer traffic on the bridge. Located at each end of the bridge were railroad-style signal towers that required trucks to stop on command. Prior to installation of the towers trucks were allowed to traverse the bridge alongside other passenger and train traffic. Once put in place the towers effectively closed off traffic for all vehicles in both directions to allow trucks to cross the bridge alone, using the full width of both of the narrow lanes. Due to numerous safety concerns, crossings by trucks were limited to daytime, with trucks being required to wait until dawn before being allowed on the bridge.

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• List of crossings of the Lower Mississippi River
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• National Register of Historic Places listings in Warren County, Mississippi