The Omsk Refinery (Russian: Омский нефтеперерабатывающий завод) is an oil refinery plant in the Russian city of Omsk, one of the largest in the country. This refinery has belonged to the Russian state-owned company Gazprom since 1995 through its subsidiary Gazprom Neft. The refinery produces over 50 different types of oil products, including gasoline, jet fuel, bitumen, and natural gas. Their products generally follow European emission standards. Its aromatics complex produces a range of aromatics of high purity: benzene (99.98% purity), p-Xylene (99.95% purity) and o-Xylene (99.6% purity).

In 1949, Soviet authorities approved the decision to construct a new oil refinery near the city of Omsk. This refinery first started operations on 6 September 1955, and began processing gasoline by 1959. It was subordinate to the Ministry of Oil Industry from 1951 to June 1957, then to the Omsk Sovnarkhoz's Oil Industry Directorate from July 1957 to 1962.

Feedstock from Bashkortostan was initially processed at Omsk. Feedstock from Siberia followed in 1964. Later feedstocks were delivered through the Ust-Balyk–Omsk pipeline.

By the mid-1970s, the refinery processed an estimated 24 million tons of oil products, the highest in the entire country.

A unit commissioned in 1994 enabled the refinery to process heavy oil and to increase oil conversion rates to 85%.

In 1995, the refinery became a part of Sibneft, which was renamed to "Gazprom" in 2006.

As of 2021, the refinery could process 22 million tons of refined petroleum products per year and the capital invested to date in the plant was 60 billion rubles.

As of 2021, the refinery was able to produce 300,000 tons of internationally-certified JET A-1 jet fuel per year. The refinery was then able to regulate "production levels for automobile and aviation fuels, as well as raw materials for lubricants. The central hydrocracking portion of the AORC also will ensure further processing of heavy petroleum fractions into diesel fuel, jet fuel, and other high-quality products in compliance with Euro 5-quality standards". The refinery now complied fully with the clean air and ecology regulations adopted under a decree of May 2018, and was fitted out with sulfur-removal technologies in order to remove 99.8% of sulfur compounds.

On 25 April 2024, Russian media reported a fire at the Omsk Refinery. The authorities used fire trains to combat the blaze. Ukraine was blamed for the fire, which engulfed three rail cars.

On 26 August 2024, an explosion and subsequent fire took place burning some 1,000 square metres (11,000 sq ft), injuring seven workers. Crude distillation unit named CDU-11, one of the "two largest primary refining units at the plant" was destroyed. The unit was responsible for roughly one-third of plant capacity. One of the seven injured later died.