One Manhattan Square (also known as 225 Cherry Street or 252 South Street) is a luxury residential skyscraper building developed by Extell Development Company in the Two Bridges neighborhood of Manhattan, New York City. Built from 2014 to 2019, the skyscraper was built on the site of a former Pathmark grocery store, which was demolished in 2014. The building topped out in 2017 and stands out significantly within the context of the neighborhood, at 847 feet (258 m) in height, the next highest structure being the Manhattan Bridge at roughly 336 feet (102 m) in height. A 13-story affordable housing component will be located separately on-site from the main tower. The building topped out in September 2017 and was complete by August 2019.

The neighborhood's residents immediately reacted to the closing of the old Pathmark supermarket, claiming that gentrification would prevent them from being able to buy affordable groceries. Once the Pathmark closed, other markets in the neighborhood became more expensive.

Other residents of the area opposed the project because the tower would be out of context with the rest of the vicinity. Its design has also been compared to a cheese grater. In fact, Extell Development Company initially proposed a tower of 68 stories or 800 feet at the site in 2014, but later reduced the scale of the tower structure to 56 stories or 700 feet. Concerns are over the transit infrastructure not being able to support such a development. However, the building wound up topping out at 80 stories.

Additionally, several dozen area residents organized into a protest in April 2015 claiming the project made unequal the future residents of the affordable housing portion and those residing in the luxury tower. Some claimed the separation of the affordable portion, restricted to a 13-story structure, acted as a "poor door" for the overall development.

• Media related to One Manhattan Square at Wikimedia Commons