Opolno-Zdrój [ɔˈpɔlnɔ ˈzdrui̯] is a village in the administrative district of Gmina Bogatynia, within Zgorzelec County, Lower Silesian Voivodeship, in south-western Poland, close to the Czech and German borders.

It lies approximately 5 kilometres (3 mi) south-west of Bogatynia, 31 kilometres (19 mi) south of Zgorzelec, and 151 kilometres (94 mi) west of the regional capital Wrocław.