Oqdaryo District (Uzbek: Oqdaryo tumani) is a district of Samarqand Region in Uzbekistan. The capital lies at the town Loyish. It has an area of 390 km (150 sq mi) and its population is 161,700 (2021 est.).

The district consists of 10 urban-type settlements (Loyish, Dahbed, Avazali, Bolta, Qirqdarxon, Kumushkent, Oytamgʻali, Oqdaryo, Yangiqoʻrgʻon, Yangiobod) and 6 rural communities.