Osina Wielka [ɔˈɕina ˈvjɛlka] is a village in the administrative district of Gmina Ziębice, within Ząbkowice Śląskie County, Lower Silesian Voivodeship, in south-western Poland.

It lies approximately 4 kilometres (2 mi) south-east of Ziębice, 19 kilometres (12 mi) east of Ząbkowice Śląskie, and 61 kilometres (38 mi) south of the regional capital Wrocław.