Pępice [pɛmˈpit͡sɛ] is a village in the administrative district of Gmina Skarbimierz, within Brzeg County, Opole Voivodeship, in south-western Poland. It lies approximately 5 kilometres (3 mi) south-west of Skarbimierz, 9 km (6 mi) south-west of Brzeg, and 42 km (26 mi) north-west of the regional capital Opole.

The village dates back to the medieval Kingdom of Poland and was first mentioned in the Liber fundationis episcopatus Vratislaviensis chronicle from the late 13th-early 14th century. Between 1871 and 1945 it was part of Germany. During World War II, the Germans established a subcamp of the Gross-Rosen concentration camp, whose prisoners were mainly Poles from Warsaw and Kraków.

There is a historic church of Our Lady of the Rosary in Pępice.