Paganico is a village in the province of Grosseto, in southern Tuscany, central Italy. It is a frazione of the comune of Civitella Paganico. It lies in the valley of the Ombrone river, at 66 meters above the sea level. In 2011 it had a population of 961 inhabitants.

The town is of medieval origins, as it was founded in the 13th century by the Republic of Siena in a strategical location overlooking the valley towards the Sienese core lands.

Sights include the Church of St Michael Archangel, built in the 13th-14th centuries. It houses a series of 14th-century frescoes (1368), attributed to the Sienese painter Biagio di Goro Ghezzi and his workshop and depicting the Stories of St. Michael, a 15th-century crucifix, and other Renaissance paintings. The town has also a line of medieval walls with several towers and gates.

• Casale di Pari
• Civitella Marittima
• Dogana, Civitella Paganico
• Monte Antico
• Pari, Civitella Paganico

• (in Italian) Paganico, Civitella Paganico official website.