Palatka High School is a public high school located in Palatka, Florida, operated by the Putnam County School Board. The school was established 1977 after merging two existing schools - Palatka Central and Palatka South. The campus has completed several renovation projects with science labs, new classrooms, a performing arts area, and office areas. Palatka High School serves the Palatka and East Palatka areas. Current student enrollment is about 1,400, drawing students from Jenkins Middle School. Students attend 7 classes per day, taking a wide variety of courses, including dual enrollment courses at St. Johns River State College. PHS offers Honors and AP courses and a variety of elective classes including Art and Journalism. Florida Virtual School is also an option for students.

• Greg Mullins — professional baseball player (Milwaukee Brewers)
• Bill Swaggerty — professional baseball player (Baltimore Orioles)
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• Willie Offord — NFL defensive back (Minnesota Vikings)
• Charles Smith — American football player
• John L. Williams — NFL running back (Seattle Seahawks) (Pittsburgh Steelers)
• Jarvis Williams — NFL safety (Miami Dolphins) (New York Giants)
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