Palmerston North Regional Hospital is the primary public hospital in Palmerston North, New Zealand. Located at the northern end of Ruahine Street, it is approximately 2 km (1.2 mi) northeast of The Square. The hospital is operated by the MidCentral District Health Board, which serves Palmerston North and the surrounding districts of Manawatū, Tararua and Horowhenua districts.

As of 2020, the hospital has 354 inpatient beds. It is a major trauma centre, one of four in the lower North Island, alongside Hawke's Bay Hospital, Whanganui Hospital and Wellington Regional Hospital.

The hospital first opened on 27 November 1893 with 25 inpatient beds across four wards, and was staffed by two doctors and three nurses. Ellen Dougherty was the hospital's first matron and became the world's first registered nurse on 10 January 1902, following the passage of the Nurses Registration Act 1901 by New Zealand Parliament.

In 1968, a 20-year-old male patient died during surgery at the hospital in New Zealand's first recorded case of malignant hyperthermia (MH), a genetic disorder which causes a severe reaction in susceptible person when exposed to certain anaesthetic agents. It was later discovered that the deceased was part of a large family based in the Manawatū region with a long history of the MH gene. As a result, approximately one in every 200 surgeries at Palmerston North Regional Hospital involves a MH-susceptible patient, compared to between 1:10,000 and 1:250,000 worldwide. New Zealand's first (and only) MH testing centre was set up at Massey University in 1978, and was taken over the hospital's anaesthetic department in 1986.

• Official website