Palmilla is a Chilean city and commune in Colchagua Province, O'Higgins Region.
According to the 2002 census of the National Statistics Institute, the commune of Palmilla spans an area of 237.3 km (92 sq mi) and has 11,200 inhabitants (5,825 men and 5,375 women). Of these, 2,088 (18.6%) lived in urban areas and 9,112 (81.4%) in rural areas. The population grew by 3.1% (336 persons) between the 1992 and 2002 censuses.
The urban area of Palmilla forms a conurbation with the city of Santa Cruz, to the south, totaling 20,691 inhabitants.
As a commune, Palmilla is a third-level administrative division of Chile administered by a municipal council, headed by an alcalde who is directly elected every four years. The 2021-2024 alcaldesa is Gloria Paredes.