Panjagutta is a commercial and residential area in western Hyderabad, India. The area contains IT hubs, shopping malls and jewellery shops. It is a major transit point for traffic between the Hyderabad districts of Ameerpet, Banjara hills, Somajiguda and Khairtabad. Twin flyovers across the road junction ease the previously heavy traffic flow.

The name Panjagutta means hand-mountain in Telugu, after a nearby peak.

• Nizam's Institute of Medical Sciences (NIMS) is also situated in here.
• Hamstech Institute of Fashion & Interior Design is located here.

Hyderabad Metro has a metro station there to connect it to other parts of city. The buses run by TSRTC connect Panjagutta to all parts of the city. There is also a mini-bus service called Setwin service. The closest MMTS Train station is at Begumpet. BSNL office is situated in Durganagar Colony.