The Parkersburg Bridge crosses the Ohio River between Parkersburg, West Virginia, and Belpre, Ohio. Designed by Jacob Linville, the bridge has 46 spans: 25 deck plate girder, 14 deck truss, 6 through truss, and 1 through plate girder. 50,000 cubic yards (38,000 m) of stone were used for the 53 piers. The bridge was constructed from May 1869 to January 1871 by the Baltimore and Ohio Railroad. At the time of its completion, the bridge was reportedly the longest in the world at 7,140 feet (2,180 m).

The approach spans were replaced 1898–1900, and the river spans were replaced 1904–1905. The original piers were retained. The steel structure atop the piers was rebuilt between about 1914 and 1917. One channel span was replaced in 1972 after a barge transporting an empty gasoline tanker exploded under the bridge.

The bridge was a part of the B&O's Baltimore – St. Louis mainline and offered the railroad easy access to Ohio in transporting coal and other materials to the east coast. Currently the bridge handles the traffic of the Belpre Industrial Parkersburg Railroad.

It was listed on the National Register of Historic Places in 1982 under the name Sixth Street Railroad Bridge. At the time of the listing, the bridge was still owned by the Baltimore and Ohio Railroad.

• List of bridges documented by the Historic American Engineering Record in Ohio
• List of bridges documented by the Historic American Engineering Record in West Virginia
• List of crossings of the Ohio River
• National Register of Historic Places listings in Wood County, West Virginia

• Track Chart, August 1947; Baltimore & Ohio System, Eastern Region, Monongah Division, Office of the Chief Engineer

Media related to Parkersburg Bridge (CSX) at Wikimedia Commons

• Historic American Engineering Record (HAER) No. WV-12, "Baltimore & Ohio Railroad, Parkersburg Bridge, Ohio River, Parkersburg, Wood County, WV", 12 photos, 10 data pages, 2 photo caption pages