Patrick St. Lawrence House, also known as the Yellow House, is a historic home located at Pittsboro, Chatham County, North Carolina. It was built about 1790, and is a two-story, center hall Georgian style architecture frame dwelling with a low gable roof. It was originally built as an inn and overlooked the courthouse square. It is Pittsboro's oldest building. It has been moved three times and is now located on S. Small St.

It was listed on the National Register of Historic Places in 1982. It is located in the Pittsboro Historic District.