Pekw'Xe:yles or Peckquaylis /pɛkˈweɪlɪs/ is an Indian reserve on the north bank of the Fraser River in Mission, British Columbia, Canada, located between Lower Hatzic Slough and D'Herbomez Creek.

Pekw'Xe:yles is 10.3 hectares large. The Fraser Valley Child Development Centre has satellite offices on the reserve.

The reserve was reinstated in June 2005 by Order in Council. It sits on the former site of St. Mary's Indian Residential School. The 2023 three-day Walk in the Spirit of Reconciliation concluded at the St. Mary’s Indian Residential School site in Mission on the Pekw'Xe:yles Reserve.

The reserve is used by 23 First Nation band governments. They are as follows.

1. Aitchelitz
2. Chawathil
3. Aitchelitz
4. Chawathil
5. Cheam First Nation
6. Kwantlen First Nation
7. Kwaw-kwaw-Apilt
8. Leq'á:mel First Nation
9. Matsqui First Nation
10. Popkum First Nation
11. Seabird Island
12. Shxw'ow'hamel First Nation
13. Shxwhá:y Village
14. Skawahlook First Nation
15. Skowkale
16. Skwah First Nation
17. Soowahlie
18. Sq'éwlets
19. Squiala First Nation
20. Sts'ailes
21. Sumas First Nation
22. Tzeachten
23. Yakweakwioose

• St. Mary's Indian Residential School
• Fraser Valley Heritage Park
• Grotto of Our Lady of Lourdes

49°08′29″N 122°16′20″W / 49.14139°N 122.27222°W / 49.14139; -122.27222