Penn House is a historic home located at Reidsville, Rockingham County, North Carolina. The main house was built in 1932, and is a 2+1⁄2-story, Colonial Revival style blond brick dwelling. The house consists of the main block; a one-story, L-shaped wing; a one-story servants' quarters; and a one-story kitchen wing behind the main block. The front facade features a full-facade, full-height portico with six Corinthian order columns. It replaced a Prairie School inspired dwelling erected on the site about 1910. Also on the property are the contributing two-story garage and servants' apartment (c. 1914–1922); smokehouse (before 1922); slate-roofed gazebo; pump house (1922-1929); and two greenhouses.

It was listed on the National Register of Historic Places in 1983. It is located in the Reidsville Historic District.