Penn State Brandywine is a commonwealth campus of the Pennsylvania State University located in Middletown Township, Pennsylvania, United States. The campus was formerly known as Penn State Delaware County. The campus has baccalaureate and associate degrees and certificate programs. The campus is located on over 112 acres (450,000 m) of grounds. In August 2017, the campus established on-campus housing for the first time with the opening of Orchard Hall, a 250-bed dormitory.

Penn State Brandywine's athletic teams, known as the Nittany Lions, compete as members of the National Collegiate Athletic Association (NCAA) Division III within the United East Conference, joining during the 2024-25 academic year. This entrance follows a successful exploratory year in the conference during the 2023-24 academic year. The men's sports teams include baseball, basketball, cross country, golf, soccer, and tennis, while the women's teams compete in basketball, cross country, soccer, softball, tennis, and volleyball.

Prior to joining the NCAA, the Nittany Lions were members of the United States Collegiate Athletic Association (USCAA) and competed in the Pennsylvania State University Athletic Conference (PSUAC).

• Official website

39°55′39″N 75°26′53″W / 39.9274°N 75.4481°W / 39.9274; -75.4481