The Peter Joplin Commercial Block is a historic commercial building at 426-443 Ouachita Street in Hot Springs, Arkansas. It is a two-story masonry structure, with retail storefronts on the ground floor and offices above. It is architecturally undistinguished, with nods toward the Tudor Revival in its styling. Built in 1905, after a fire had swept through the area, it is one of the only buildings in the area to survive an even larger fire in 1913. As such, it is a rare surviving example of early 20th century commercial architecture.

The building was listed on the National Register of Historic Places in 2000.

• National Register of Historic Places listings in Garland County, Arkansas