Phayuha Khiri (Thai: พยุหะคีรี, pronounced [pʰā.jú.hàʔ kʰīː.rīː]) is a district (amphoe) in Nakhon Sawan province, central Thailand.

Phayuha Khiri is an ancient city. It was at the midpoint of two larger cities, Phra Bang (today Nakhon Sawan) and Chainat Buri (today Chai Nat), along the standard military route used by troops of Sukhothai and Ayutthaya.

Recently the district office was relocated to Tambon Sa Thale.

Its name "Phayuha Khiri" meaning "procession of the mountains", since the area consists of many small and large hills. Some hills are beautiful and are home to both temples and Buddha statues on the top.

Neighbouring districts are (from the north clockwise): Krok Phra, Mueang Nakhon Sawan, Tha Tako, Tak Fa, and Takhli of Nakhon Sawan Province; Manorom of Chai Nat province; and Mueang Uthai Thani of Uthai Thani province.

The district is divided into 11 sub-districts (tambons), which are further subdivided into 125 villages (mubans). There are two sub-district municipalities (thesaban tambon): Phayuha covering parts of tambon Phayuha, and Tha Nam Oi covering tambons Tha Nam Oi and Muang Hak. There are a further nine tambon administrative organizations (TAO).

No.	Name	Thai	Villages	Pop.
01.	Phayuha	พยุหะ	09	10,851
02.	Noen Makok	เนินมะกอก	12	05,803
03.	Nikhom Khao Bo Kaeo	นิคมเขาบ่อแก้ว	16	06,369
04.	Muang Hak	ม่วงหัก	10	02,299
05.	Yang Khao	ยางขาว	09	03,907
06.	Yan Matsi	ย่านมัทรี	07	04,785
07.	Khao Thong	เขาทอง	12	07,488
08.	Tha Nam Oi	ท่าน้ำอ้อย	08	02,840
09.	Nam Song	น้ำทรง	11	06,386
10.	Khao Kala	เขากะลา	19	08,552
11.	Sa Thale	สระทะเล	12	03,228

Phayuha Khiri is the location of Mahidol University Nakhon Sawan Campus.

• amphoe.com